J Physiol Biochem. Inhibitory effects of 1alpha, 25dihydroxyvitamin D3 and Ajuga iva extract on oxidative stress, toxicity and hypo-fertility in diabetic rat testes. Thus diabetic rats were treated with 1alpha, 25dihydroxyvitaminD3 or Ajuga iva extract as both therapeutic and preventive treatments on diabetes toxicity in rats testes. Our results showed that diabetes induced a decrease in testosterone and 17beta-estradiol levels in testes and plasma. Besides, a fall in testicular antioxidant capacity appeared by a decrease in both antioxidant superoxide dismutase SOD , catalase CAT and glutathione peroxidase GPx activities and nonenzymatic antioxidant copper Cu , magnesium Mg and iron Fe levels. All theses changes enhanced testicular toxicity increase in testicular aspartate amino transaminase AST , alanine amino transaminase ALT , lactate dehydrogenase LDH activities and the lipid peroxidation and triglyceride TG levels.
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Acute and chronic toxicological studies of Ajuga iva in experimental animals.
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